Biocompatibility Cytotoxicity Testing of Orthopedic Implants

cytotoxicity testing for Titanium Alloy Artificial Joints 

Titanium alloy artificial joints are used for hip and knee replacements, requiring long-term mechanical load-bearing and integration with bone tissue. China JJR Laboratory provides biocompatibility and cytotoxicity testing services.

Why is Cytotoxicity Testing Necessary? 

Risk Factors: 

Metal wear particles (e.g., titanium and aluminum ions) may induce osteoblast apoptosis or cause osteolysis.

Necessity: 

Ensuring that materials do not release toxic substances under prolonged friction, which could affect bone regeneration.

EU Standards and Testing Methods 

- ISO 10993-5: Quantitative evaluation of extract inhibition rates on osteoblast cell lines using the MTT assay. 

- ISO 21534: Orthopedic implant-specific standard requiring dynamic mechanical testing in conjunction with biocompatibility analysis.

Other Biocompatibility Tests 

- Local Tissue Response: Rabbit muscle implantation tests assess inflammation and fibrosis levels. 

- Fatigue Performance Testing: Simulating material durability under human motion loads. 

- Corrosion Testing: Electrochemical analysis of ion release levels.

Cytotoxicity Testing Cost 

China JJR Laboratory, a GLP-accredited lab, offers cytotoxicity testing at a cost ranging from $500 to $600.